Lymphatic function is required prenatally for lung inflation at birth
Identifieur interne : 002898 ( Main/Exploration ); précédent : 002897; suivant : 002899Lymphatic function is required prenatally for lung inflation at birth
Auteurs : Zoltán Jakus ; Jason P. Gleghorn ; David R. Enis ; Aslihan Sen ; Stephanie Chia ; Xi Liu ; David R. Rawnsley ; Yiqing Yang ; Paul R. Hess ; Zhiying Zou ; Jisheng Yang ; Susan H. Guttentag ; Celeste M. Nelson ; Mark L. KahnSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 2014.
Abstract
Neonatal mice lacking lymphatic vessels due to loss of lymphangiogenic factor CCBE1 or VEGFR3 function fail to inflate their lungs, suggestive of respiratory failure in infants with congenital pulmonary lymphangiectasia.
Url:
DOI: 10.1084/jem.20132308
PubMed: 24733830
PubMed Central: 4010903
Affiliations:
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Enis</name><affiliation><nlm:aff id="aff1"><institution>Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104</institution></nlm:aff></affiliation></author><author><name sortKey="Sen, Aslihan" sort="Sen, Aslihan" uniqKey="Sen A" first="Aslihan" last="Sen">Aslihan Sen</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Chia, Stephanie" sort="Chia, Stephanie" uniqKey="Chia S" first="Stephanie" last="Chia">Stephanie Chia</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Xi" sort="Liu, Xi" uniqKey="Liu X" first="Xi" last="Liu">Xi Liu</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Fourth Military Medical University, Xi’an 710032, China</institution></nlm:aff></affiliation></author><author><name sortKey="Rawnsley, David R" sort="Rawnsley, David R" uniqKey="Rawnsley D" first="David R." last="Rawnsley">David R. 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Gleghorn</name><affiliation><nlm:aff id="aff2"><institution>Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544</institution></nlm:aff></affiliation></author><author><name sortKey="Enis, David R" sort="Enis, David R" uniqKey="Enis D" first="David R." last="Enis">David R. Enis</name><affiliation><nlm:aff id="aff1"><institution>Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104</institution></nlm:aff></affiliation></author><author><name sortKey="Sen, Aslihan" sort="Sen, Aslihan" uniqKey="Sen A" first="Aslihan" last="Sen">Aslihan Sen</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Chia, Stephanie" sort="Chia, Stephanie" uniqKey="Chia S" first="Stephanie" last="Chia">Stephanie Chia</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Liu, Xi" sort="Liu, Xi" uniqKey="Liu X" first="Xi" last="Liu">Xi Liu</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Fourth Military Medical University, Xi’an 710032, China</institution></nlm:aff></affiliation></author><author><name sortKey="Rawnsley, David R" sort="Rawnsley, David R" uniqKey="Rawnsley D" first="David R." last="Rawnsley">David R. Rawnsley</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Yang, Yiqing" sort="Yang, Yiqing" uniqKey="Yang Y" first="Yiqing" last="Yang">Yiqing Yang</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Hess, Paul R" sort="Hess, Paul R" uniqKey="Hess P" first="Paul R." last="Hess">Paul R. Hess</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Zou, Zhiying" sort="Zou, Zhiying" uniqKey="Zou Z" first="Zhiying" last="Zou">Zhiying Zou</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Yang, Jisheng" sort="Yang, Jisheng" uniqKey="Yang J" first="Jisheng" last="Yang">Jisheng Yang</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author><author><name sortKey="Guttentag, Susan H" sort="Guttentag, Susan H" uniqKey="Guttentag S" first="Susan H." last="Guttentag">Susan H. Guttentag</name><affiliation><nlm:aff id="aff4"><institution>Department of Neonatology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104</institution></nlm:aff></affiliation></author><author><name sortKey="Nelson, Celeste M" sort="Nelson, Celeste M" uniqKey="Nelson C" first="Celeste M." last="Nelson">Celeste M. Nelson</name><affiliation><nlm:aff id="aff2"><institution>Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544</institution></nlm:aff></affiliation></author><author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><affiliation><nlm:aff id="aff1"><institution>Department of Medicine</institution>,</nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff1"><institution>Cardiovascular Institute</institution></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Experimental Medicine</title><idno type="ISSN">0022-1007</idno><idno type="eISSN">1540-9538</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Neonatal mice lacking lymphatic vessels due to loss of lymphangiogenic factor CCBE1 or VEGFR3 function fail to inflate their lungs, suggestive of respiratory failure in infants with congenital pulmonary lymphangiectasia.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, F H" uniqKey="Adams F">F.H. 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Rawnsley</name><name sortKey="Sen, Aslihan" sort="Sen, Aslihan" uniqKey="Sen A" first="Aslihan" last="Sen">Aslihan Sen</name><name sortKey="Yang, Jisheng" sort="Yang, Jisheng" uniqKey="Yang J" first="Jisheng" last="Yang">Jisheng Yang</name><name sortKey="Yang, Yiqing" sort="Yang, Yiqing" uniqKey="Yang Y" first="Yiqing" last="Yang">Yiqing Yang</name><name sortKey="Zou, Zhiying" sort="Zou, Zhiying" uniqKey="Zou Z" first="Zhiying" last="Zou">Zhiying Zou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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